Superoxide Dismutase and Oxidase Activities of Copper(II) Complexes of the Anti-inflammatory Drug Ibuprofen with Imidazoles and Pyrazole

Ibuprofen a non-steroidal anti-inflammatory drug (NSAID) is among the most prescribed drug on the world. Copper(II) complexes with NSAIDs are more active than their parent drugs and exhibit a lower toxicity than inorganic forms of copper [1] . Further, many of these complexes, including that of copper ibuprofenate complex, have a better anti-ulcer protective effect than the parent drugs. Binary and some ternary copper(II) ibuprofenate complexes are dimeric of the general formula Cu2(Ibup)4L2, where L is solvent or monodentate ligands , and having the known paddlewheel dicopper(II) tetracarboxylates structure [2].